Building and scaling a profitable eCommerce business requires a comprehensive strategy that encompasses various aspects. Here are the top 5 things to focus on:

1. Product Selection and Differentiation:
Start by identifying a niche or product category with high demand and low competition. Conduct market research to understand customer needs, preferences, and trends. Look for unique product differentiators that set you apart from competitors. For example, if you plan to sell clothing, consider offering sustainable or ethically sourced materials like Patagonia does. This will attract environmentally conscious customers and provide a competitive advantage.

2. User-Friendly Website and Seamless Shopping Experience:
Invest in a well-designed, user-friendly eCommerce website that provides a seamless shopping experience. Ensure it is mobile-responsive and optimized for fast loading speeds. Implement intuitive navigation, clear product descriptions, high-quality images, and customer reviews to build trust. Use persuasive copywriting techniques and compelling visuals to enhance the overall shopping experience. Shopify and WooCommerce are popular platforms for setting up eCommerce websites.

3. Effective Digital Marketing and Customer Acquisition:
Develop a comprehensive digital marketing strategy to drive traffic and acquire customers. This may include search engine optimization (SEO), pay-per-click (PPC) advertising, social media marketing, content marketing, and email marketing. Utilize tools like Google Analytics to track website traffic, conversion rates, and customer behavior. Implement retargeting campaigns to re-engage potential customers who have shown interest but not made a purchase yet. For example, Casper, a mattress company, effectively utilizes digital marketing channels to drive customer acquisition.

4. Streamlined Order Fulfillment and Customer Service:
Efficient order fulfillment and exceptional customer service are crucial for building customer loyalty and positive reviews. Implement a robust inventory management system to ensure accurate stock levels and timely order processing. Offer multiple shipping options, including fast and reliable delivery services. Provide proactive communication, order tracking, and hassle-free returns to enhance the customer experience. Companies like Amazon have set high standards in order fulfillment and customer service, which have contributed to their success.

5. Data-Driven Decision Making and Continuous Improvement:
Leverage data analytics to make informed business decisions and continuously improve your eCommerce operations. Monitor key performance indicators (KPIs) such as customer acquisition cost (CAC), customer lifetime value (CLTV), conversion rates, and average order value (AOV). Analyze customer behavior, preferences, and feedback to identify areas for improvement. Utilize tools like Google Analytics, Hotjar, and Kissmetrics to gain insights into customer journeys, website usability, and conversion funnels. Implement A/B testing to optimize website elements, pricing strategies, and marketing campaigns.

Remember, building a profitable eCommerce business takes time, effort, and ongoing optimization. It's important to adapt and iterate based on customer feedback and market dynamics.